Clinical and translational allergy
Is It Safe to Reduce Inhaled Corticosteroid Dose in Severe Asthma Patients Receiving Biologic Therapy?
Par Özer NO, Öztürk BÖ, Akın BG et 2 autres.
Contenu en anglais
Résumé
Background
Biologic therapies can control severe asthma and may modify its natural history beyond symptom control. However, step-down is not standardized, and its safety has not been clearly established.
Methods
This single-center retrospective cohort study reviewed adults with severe asthma on biologics (January 2019-May 2024). Step-down strategies (discontinuation of add-on therapy and/or inhaled corticosteroid [ICS] dose reduction) were described, success rates calculated, and clinical characteristics compared between groups with and without step-down.