RAS-Pathway Mutation Profiles and Clinical Outcomes Among Patients With Colorectal Cancer

Background

Somatic alterations in the RAS-RAF-MAPK and PI3K pathways are key in colorectal cancer (CRC), yet their distribution, co-occurrence patterns, and clinical significance remain incompletely defined. We characterized RAS/MAPK- and PI3K-pathway alterations in a large cohort and assessed their prognostic implications.

Methods