PeerJ
Correlation between BRCA mutational status and lymph node metastasis in advanced epithelial ovarian cancer: a retrospective study
Par Guan M, Wang X, Ma Y et 4 autres.
Contenu en anglais
Résumé
Objective
To clarify the association between breast cancer (BRCA) mutations and clinically relevant factors, with a particular focus on lymph node metastasis (LNM), in patients with advanced epithelial ovarian cancer (EOC).
Methods
This retrospective single-center study included patients with histologically confirmed advanced EOC and known BRCA status. Comprehensive clinical, surgical, and pathological data were collected, and survival outcomes were obtained through follow-up. Associations between BRCA mutations and clinicopathological variables were analyzed using univariate and multivariate models. Progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan-Meier analysis and Cox proportional hazards regression.