Study on tumor ecology and precision medicine strategy of oral squamous cell carcinoma based on multi-omics cell atlas

Introduction

Oral squamous cell carcinoma (OSCC) is characterized by inter- and intratumoral heterogeneity, which complicates patient stratification and treatment. Although single-cell studies have improved the resolution of the OSCC microenvironment, the relationships among cellular states, spatial organization, immune-repertoire dynamics, and patient-level ecosystem patterns remain incompletely understood.