The hepatoprotective impacts of Citrullus colocynthis seeds extract on type 1 diabetes-induced liver inflammation and oxidative stress in rats: The role of nrf2/keap1 pathway

Objective

Type 1 Diabetes (T1D) induces several consequences including hepatic damage resulting from oxidative stress and inflammation. The Nrf2/Keap1 pathway is crucial in oxidative stress signaling, and its modifications significantly influence health and illness. In this study, rats with T1D were used to test Citrullus colocynthis (CC) ability to reduce oxidative stress and inflammation in the diabetic liver.

Materials and methods