Efficacy and safety of double plasma cytokine adsorption system with sequential low-volume plasma exchange in treating acute-on-chronic liver failure complicated by sepsis: protocol for a multicentre randomised controlled clinical trial

Introduction: Acute-on-chronic liver failure (ACLF) and sepsis are both life-threatening clinical syndromes that frequently coexist. Patients with ACLF complicated by sepsis experience significantly higher mortality rates, yet therapeutic options remain limited. This randomised controlled trial aims to evaluate the efficacy and safety of the double plasma cytokine adsorption system with sequential low-volume plasma exchange (DPCAS+LPE) in patients with ACLF complicated by sepsis.