Implementing polygenic risk scores for breast cancer prevention: protocol for a feasibility study in a real-world clinical setting

Introduction: Polygenic risk scores (PRSs) enhance breast cancer risk prediction when integrated into multifactorial models such as CanRisk. However, evidence on the real-world feasibility of incorporating PRS into routine hereditary breast cancer pathways remains limited, particularly within southern European healthcare systems. This study aims to evaluate the feasibility and acceptability of integrating PRS into clinical risk assessment in a real-world setting in Italy.