Gut pathogens
Association of Blastocystis subtype 3 with elevated IL-8-mediated inflammation in patients with irritable bowel syndrome
Par Morsy SM, Abdeltawab MSA, Mahfoz AM et 3 autres.
Contenu en anglais
Résumé
Background
The role of Blastocystis in the pathophysiology of irritable bowel syndrome (IBS) remains controversial, with emerging evidence suggesting subtype-specific differences in pathogenicity. Interleukin-8 (IL-8), a key pro-inflammatory chemokine, has been implicated in mucosal immune activation in both IBS and parasitic infections.
Objective
This study aimed to investigate the association between Blastocystis subtypes and clinical manifestations of IBS, with a particular focus IL-8 as part of the systemic pro-inflammatory immune response associated with functional GIT disorders and intestinal infections.