BMC ophthalmology
Beyond motor recovery: subthalamic nucleus deep brain stimulation may improve blinking and dry eye symptoms without restoring tear film homeostasis in Parkinson's disease
Par Hamzaoğlu EC, Hamzaoğlu V, Ateş U et 3 autres.
Contenu en anglais
Résumé
Purpose
To investigate the longitudinal effects of subthalamic nucleus deep brain stimulation (STN-DBS) on objective and subjective dry eye parameters in patients with Parkinson's disease (PD).
Methods
This retrospective observational study included 34 patients with advanced PD who underwent STN-DBS. Comprehensive ophthalmic examinations were performed were performed before surgery and at postoperative week 1, month 1, and month 4. Outcome measures included spontaneous blink rate, tear break-up time (TBUT), Schirmer I test, Oxford corneal staining score, and the Ocular Surface Disease Index (OSDI). Longitudinal changes were analyzed using generalized estimating equations (GEE).