Astrocyte-enriched and cilia-related genetic signatures in dementia: A whole-exome sequencing study

Background

Alzheimer's disease (AD), the most prevalent form of dementia, is highly heritable, yet much of its genetic basis remains unexplained. Most genetic studies have focused on European populations, with limited data from under-represented groups. Whole-exome sequencing (WES) in the Han Chinese population may help identify novel rare variants and population-specific genetic risk factors.