Impact of opioid use disorder on oxytocin required for labor induction in term pregnancies

Objective

Oxytocin is a neuropeptide proven to impact human labor, lactation, and social affinity and is of interest in the study of pain and μ-opioid receptor modulation. Individuals impacted by opioid use disorder (OUD) frequently have μ-opioid receptor dysregulation. In this study, we sought to investigate the effect of OUD on the effectiveness of synthetic oxytocin in term inductions of labor.