Kidney international reports
Long-Term Opioid and Gabapentinoid Related Harms in CKD
Par Grant CH, Livingstone S, Wang H et 4 autres.
Contenu en anglais
Résumé
Introduction
Chronic pain affects over half of the patients with chronic kidney disease (CKD). This study aimed to evaluate the association between new long-term opioids or gabapentinoids and the risk of death, hospitalization, and hip fractures in adults with CKD.
Methods
This is a retrospective, time-updated, population-based cohort study from the East of Scotland (N = 953,542) using linked routinely collected data. The study population included adults with biochemically confirmed CKD (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m2) without kidney failure from 2010 to 2023. The primary exposures were new, long-term cumulative opioids or gabapentinoids. Discrete time logistic regression modelling with generalized estimating equations and adjustment for relevant covariates and treatment allocation bias was used to determine the association between chronic analgesic use and all-cause mortality.