The AGT M235T variant and renin-angiotensin-aldosterone system parameters in a predominantly hypertensive elderly black South African cohort: a hypothesis-generating descriptive case series

Background

Hypertension (HTN) is a key cardiovascular risk factor, with its pathogenesis remaining incompletely understood. Blood pressure (BP) regulation involves the Renin-Angiotensin-Aldosterone System (RAAS), including the Angiotensin-converting enzyme (ACE), Angiotensin I (Ang I) and Angiotensin II (Ang II). The rs699 variant (M235T) may influence BP via the RAAS.