Alzheimer's & dementia : the journal of the Alzheimer's Association
Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers
Par Quiring M, Kapoor A, Alitin JPM et 14 autres.
Contenu en anglais
Résumé
Introduction
It remains unclear whether medial temporal lobe (MTL) hyperperfusion in cognitively unimpaired apolipoprotein E (APOE) ɛ4 carriers reflects resilience or dysfunction. We examined whether cortical MTL cerebral blood flow (CBF) relates to cognition differently in APOE ɛ4 carriers and noncarriers with and without AD pathophysiological changes.