Zhonghua yi xue za zhi
A systematic review and meta-analysis of effectiveness of influenza vaccine among healthcare workers
Par Liu XY, Zhao HT, Yang XK et 5 autres.
Contenu en anglais
Résumé
Objective
To systematically evaluate the protective effect of influenza vaccine among healthcare workers (HCW).
Methods
Relevant literature from January 1, 2000 to November 4, 2025, was retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China National Biomedical Literature Service System, National Library of Medicine database, Dutch Medical Abstracts database, and Cochrane Collaboration Library. Two independent researchers screened the literature, extracted data and assessed the quality of the studies, based on predefined inclusion and exclusion criteria. Studies using cohort design and test-negative design were included. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. A meta-analysis was performed using R software version 4.3.3, with vaccine effectiveness (VE) as the effect measure, to calculate the effectiveness of influenza vaccine among HCW.