Case Report: mNGS-negative Strongyloides hyperinfection syndrome with small bowel obstruction as the initial manifestation in a glucocorticoid-exposed COPD patient: a fatal case

Background

Strongyloides hyperinfection syndrome (SHS) is a life-threatening condition in immunocompromised hosts with an extremely high mortality rate. Metagenomic next-generation sequencing (mNGS) demonstrates limited sensitivity for parasitic detection, and its clinical value remains to be fully elucidated. The conventional microscopy remains an indispensable tool for the diagnosis of parasitic infections.