Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients-A Post Hoc Bayesian Analysis of the AID-ICU Trial

Delirium is clinically classified into hypoactive or hyperactive motoric subtypes, which may have different responses to treatment. We assessed heterogeneity in treatment effects according to baseline motoric subtype in the AID-ICU trial, which randomised adult ICU patients with delirium to haloperidol versus placebo.

In this post hoc study of the AID-ICU trial, we used adjusted Bayesian linear and logistic regression models to assess potential differential effects of haloperidol on 90-day outcomes according to motor subtypes. Effect estimates are reported as absolute differences within and between subtypes (mean differences (MD)/risk differences (RD) and differences in MDs/RDs), with probabilities of any benefit, any harm and differential effects between subtypes.