ETS-related gene Immunohistochemical Expression as a Surrogate for TMPRSS2::ERG Fusion in Nigerian Prostate Adenocarcinoma: Clinicopathological Correlates

Background

The Transmembrane serine protease 2- ETS-related gene (TMPRSS2::ERG) fusion is the most frequent genomic alteration in prostate adenocarcinoma (PCa) and can be reliably detected using ERG immunohistochemistry (IHC) as a surrogate marker. Data regarding ERG expression in indigenous African populations are scarce. This study evaluated ERG immunohistochemical expression and its clinicopathological correlates in Nigerian patients with prostate adenocarcinoma.