Dexamethasone-Induced Insulin Resistance and Hepatic Metabolic Dysfunction: Modulatory Effects of Montelukast on SGK1-Associated Signaling and NLRP3/Leukotriene-Related Responses

Background

Glucocorticoid-induced metabolic dysfunction and insulin resistance-related abnormalities are important complications associated with dexamethasone (DEX) exposure. This study investigated the protective effects of montelukast (MNT) against DEX-induced metabolic and hepatic disturbances and characterized associated oxidative, inflammatory, leukotriene-related, and insulin-signaling changes in rats.