Targeting Cholinergic Dysfunction and Gingipain Activity in Alzheimer’s Disease: A Dual AChE–Kgp Computational Study

Introduction

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder for which single-target strategies may be insufficient. This study explored a host–microbial multitarget strategy using a CNS-oriented small molecule predicted to engage both human acetylcholinesterase (AChE) and Porphyromonas gingivalis lysine-specific gingipain K (Kgp).