TOLLIP and MUC5B Genetic Variants Influence the Circulating KL6, SPD, and HE4 Levels in Interstitial Lung Abnormalities

Background

Interstitial lung abnormalities (ILAs) are alterations of lung parenchyma found in approximately 5% of individuals older than 60 years. There is growing interest in identifying early biomarkers that may facilitate diagnosis and predict disease progression. Given ILA’s biological complexity, a multidimensional approach integrating genetic susceptibility and immune dysregulation is warranted.