Prognostic Value of the KELIM Score Versus Conventional CA-125 Kinetics in Ovarian Cancer: A Systematic Review and Meta-Analysis

Background/Objectives: To compare the prognostic value of the modeled cancer antigen-125 (CA-125) elimination rate constant K (KELIM) with that of conventional CA-125 kinetics (e.g., half-life) in epithelial ovarian cancer.

Methods

PubMed, EMBASE, and Cochrane CENTRAL were searched from inception to 8 July 2026, using terms for ovarian cancer, CA-125 kinetics (KELIM, half-life, nadir), platinum-based chemotherapy, and survival or cytoreduction. Hazard ratios (HRs) and odds ratios (ORs) were pooled using random-effects models.