Prospective External Validation of the HFA-ICOS Baseline Cardiovascular Risk Classification in Women with Breast Cancer Receiving Anthracycline-Containing Therapy in a Central Asian Cohort

Background/Objectives: The HFA-ICOS baseline cardiovascular risk classification was developed to standardize pretreatment risk stratification before potentially cardiotoxic cancer therapy, but its external performance across diverse populations remains incompletely characterized. We prospectively evaluated its performance in women with breast cancer receiving anthracycline-containing therapy in Central Asia.