Cell-Free DNA-Based Blood Tests for Colorectal Cancer Screening: Current Advances, Challenges, and Future Perspectives

Background

Colorectal cancer (CRC) is a major cause of rising global rates of cancer-related morbidity and mortality. CRC rates are particularly increasing among younger populations; however, the implementation of effective CRC screening programs remains limited. Colonoscopy, the gold standard CRC screening technique, is restricted by complex procedures, invasive methods, and low patient adherence. Therefore, non-invasive screening through circulating cell-free DNA (cfDNA)-based blood tests is emerging as an effective alternative.