International Journal of Science and Research
Toxicity of High-Dose Methotrexate and Its Correlation with Serum Levels in Adult Acute Lymphoblastic Leukaemia
Par D Srujana, Kashinath Benakatti, Darshan R S et 5 autres.
Contenu en anglais
Résumé
Background
High-dose methotrexate (HDMTX) is central to consolidation in acute lymphoblastic leukaemia (ALL) but causes substantial toxicity, and data on adults are limited.
Methods
We retrospectively analysed 400 HDMTX cycles (5 g/m2) given to 106 adults with ALL on the BFM-95 protocol at Kidwai Memorial Institute of Oncology, Bengaluru (June 2023-November 2024). Toxicity was graded by CTCAE v5.0 and related to serum methotrexate levels at 48 and 72 hours (toxic: >1 and >0.1 ?mol/L).