Cardiology Research
Association Between Hepatitis C Virus Infection and Coronary Artery Disease: A Systematic Review and Meta-Analysis
Par Ali Alhashli.
Contenu en anglais
Résumé
Background
Hepatitis C virus (HCV) infection has been associated with cardiovascular disease, but its relationship with coronary artery disease (CAD) remains uncertain.
Methods
This systematic review included observational studies reporting adjusted effect estimates for CAD outcomes among HCV-infected and HCV-uninfected adults. Adjusted hazard ratios, risk ratios, and odds ratios were combined on the logarithmic scale using a random-effects model and are presented as a summary relative association estimate with 95% confidence intervals (CIs). Prespecified subgroup analyses were performed by study design, human immunodeficiency virus (HIV) co-infection status, and CAD outcome type; meta-regression evaluated follow-up duration, mean age, and the proportion of male participants.