Chinese Medicine Led As-Doped Carbon Dot Nanoformulation for Effective Against Acute Promyelocytic Leukemia in Xenograft Model

Purpose

Acute promyelocytic leukemia (APL) is effectively treated with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA), but arsenic-associated systemic toxicity remains an important clinical concern. This study aimed to develop a traditional Chinese medicine-inspired arsenic-doped carbon dot nanoplatform for APL therapy.